A systematic review of two human studies found that mangosteen peel extract may improve insulin sensitivity by 53.2% and reduce fasting blood glucose in people with type 2 diabetes, though evidence remains limited.
- Mangosteen peel extract improved insulin sensitivity by 53.2% compared to 15.2% with placebo after 26 weeks in one trial
- A second small study showed reduced fasting blood glucose after 7 days of mangosteen peel decoction
- Only two human studies met review criteria, limiting the strength of conclusions
How this compares to prior research
Type 2 diabetes is characterized by insulin resistance and chronic inflammation, prompting interest in natural therapies. Mangosteen peel contains xanthone compounds with potential antidiabetic properties, but prior to this review, clinical evidence in humans was scattered. Most previous research focused on animal models or laboratory studies rather than human trials.
Key findings
- Insulin sensitivity improved significantly more with mangosteen extract (HOMA-IR reduction of 53.2%) compared to placebo (15.2% reduction) over 26 weeks
- Fasting blood glucose decreased significantly after 7 days of mangosteen peel decoction in a small quasi-experimental study
- Only two human studies met inclusion criteria, both with small sample sizes and one with short follow-up duration
What this means in practice
- Ask your doctor before using mangosteen supplements, as evidence is limited and extract quality varies widely
- Consider that only two small studies support these findings, so results may not apply broadly
- Monitor your blood sugar closely if trying any natural supplement alongside diabetes medications
Frequently asked questions
What is mangosteen peel extract?
Mangosteen peel extract comes from the rind of the mangosteen fruit and contains xanthone compounds that may have antidiabetic properties. It has been studied as a natural supplement for type 2 diabetes.
How much did mangosteen extract improve insulin sensitivity?
In one 26-week trial, mangosteen extract improved insulin sensitivity by 53.2% compared to 15.2% with placebo, as measured by HOMA-IR scores.
Is mangosteen peel extract proven to treat diabetes?
No. Only two small human studies exist, with short follow-up periods and different extract preparations. Larger randomized trials are needed before clinical recommendations can be made.
Key terms explained
HOMA-IR
Homeostatic Model Assessment for Insulin Resistance, a measure of how well insulin controls blood sugar levels
Xanthone
A type of natural compound found in mangosteen peel with potential anti-inflammatory and antidiabetic effects
HbA1c
Hemoglobin A1c, a blood test showing average blood sugar levels over the past 2-3 months