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According to clinical guidelines, several groups should avoid or use melatonin with caution:
- Pregnant or breastfeeding women due to limited safety data
- People with autoimmune disorders as it may increase immune system activity
- Those with bleeding disorders or taking blood thinners
- Individuals with seizure disorders or depression
Additionally, people taking certain medications should consult their healthcare provider before using melatonin, including those on:
- Blood pressure medications
- Diabetes medications
- Birth control pills
Children should only take melatonin under medical supervision.
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Last Updated: August 22, 2025
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