Research indicates that certain groups should avoid or use extreme caution with melatonin supplements:
- Pregnant or breastfeeding women due to limited safety data
- People with autoimmune disorders as it may increase inflammation
- Those with bleeding disorders or taking blood thinners
- People with epilepsy or seizure disorders
- Individuals with depression or other psychiatric conditions
Additionally, people taking certain medications (including blood pressure medications, diabetes medicines, and immunosuppressants) should consult their healthcare provider before using melatonin, as it may interact with these medications. Children and teenagers should only use melatonin under medical supervision.
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Last Updated: September 7, 2025
Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult with a healthcare provider before making health decisions.
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