While melatonin is generally considered safe for short-term use, research has identified several potential side effects:
- Common side effects: Headache, dizziness, nausea, daytime sleepiness
- Less common effects: Vivid dreams, nightmares, mild anxiety
- Rare side effects: Depression, mild tremor, mild cramps
Long-term use may affect hormonal development in children and teenagers. Studies show melatonin can interact with various medications, including blood thinners, diabetes medications, and immunosuppressants. Always consult healthcare providers before starting supplementation, especially if taking other medications.
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Last Updated: October 13, 2025
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