While melatonin is generally considered safe for short-term use, research has identified several possible side effects:
- Common side effects: Headaches, dizziness, daytime sleepiness
- Less common effects: Mild anxiety, temporary depression, mild tremors
- Rare side effects: Mild nausea, temporary changes in blood pressure
Long-term use should be discussed with a healthcare provider. Studies show melatonin can interact with various medications, including blood thinners, diabetes medications, and immunosuppressants. It’s particularly important to avoid alcohol consumption when taking melatonin, as this can increase side effects.
✓ Expert Reviewed: This content has been reviewed by qualified professionals in the field.
Last Updated: October 5, 2025
Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult with a healthcare provider before making health decisions.
Editorial Standards: Our Medical Content StandardsThe Health Research Team is a collaborative network of healthcare professionals, graduate researchers, and medical science students dedicated to synthesizing peer-reviewed health research for public education. Our interdisciplinary approach combines expertise from nutrition science, physiotherapy, nursing, and medical research to provide comprehensive, evidence-based health information.Click to read our Editorial Policy in details - Medical Oversight: All health information is overseen by board-certified physicians and follows FDA guidelines for health content