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While melatonin is generally considered safe for short-term use, research has identified several possible side effects:

  • Common side effects: Headache, dizziness, daytime sleepiness
  • Less common effects: Mild anxiety, temporary depression, mild tremor
  • Rare side effects: Mild nausea, confusion, vivid dreams

Long-term use should be monitored by a healthcare provider. Studies show that melatonin can interact with certain medications, including blood thinners and diabetes medications. Pregnant women and those with autoimmune conditions should consult their doctor before use.

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Last Updated: September 11, 2025

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