While melatonin is generally considered safe for short-term use, research has identified several possible side effects:
- Common side effects: Headache, dizziness, nausea, daytime sleepiness
- Less common effects: Vivid dreams, nightmares, mild anxiety
- Rare side effects: Depression, mild tremor, mild anxiety, abdominal cramps
Long-term use may also affect hormonal development, particularly in adolescents. Studies show melatonin can interact with various medications, including blood thinners, diabetes medications, and immunosuppressants. It’s important to discuss melatonin use with a healthcare provider, especially if you have existing medical conditions or take other medications.
✓ Expert Reviewed: This content has been reviewed by qualified professionals in the field.
Last Updated: September 3, 2025
Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult with a healthcare provider before making health decisions.
Editorial Standards: Our Medical Content StandardsThe Health Research Team is a collaborative network of healthcare professionals, graduate researchers, and medical science students dedicated to synthesizing peer-reviewed health research for public education. Our interdisciplinary approach combines expertise from nutrition science, physiotherapy, nursing, and medical research to provide comprehensive, evidence-based health information.Click to read our Editorial Policy in details - Medical Oversight: All health information is overseen by board-certified physicians and follows FDA guidelines for health content