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While melatonin is generally considered safe for short-term use, studies have documented several possible side effects:

  • Common side effects: Headache, dizziness, daytime sleepiness
  • Less common effects: Mild anxiety, temporary depression, mild tremor
  • Rare side effects: Mild nausea, confusion, vivid dreams

Long-term use may affect hormonal development, particularly in adolescents. Melatonin can also interact with various medications, including blood thinners, diabetes medications, and immunosuppressants. It’s important to consult with a healthcare provider before starting melatonin, especially if you have existing medical conditions or take other medications.

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Last Updated: August 30, 2025

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