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While melatonin is generally considered safe for short-term use, studies indicate several possible side effects:

  • Common side effects:
    • Headache
    • Dizziness
    • Daytime sleepiness
    • Short-term feelings of depression
  • Less common side effects:
    • Mild anxiety
    • Temporary changes in blood pressure
    • Vivid dreams or nightmares

Long-term effects are still being studied. Melatonin may interact with various medications, including blood thinners and diabetes medications. Pregnant women, nursing mothers, and people with autoimmune disorders should avoid melatonin supplements unless specifically recommended by their healthcare provider.

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Last Updated: October 21, 2025

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