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While melatonin is generally considered safe for short-term use, studies have identified several possible side effects:

  • Common side effects: Headache, dizziness, daytime sleepiness
  • Less common effects: Nausea, mild anxiety, temporary depression
  • Rare effects: Vivid dreams, nightmares, slight changes in blood pressure

Long-term effects are still being studied. Melatonin can interact with various medications, including blood thinners and diabetes medications. It’s important to consult a healthcare provider before starting supplementation, especially if you have existing medical conditions.

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Last Updated: September 5, 2025

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