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While melatonin is generally considered safe for short-term use, some people may experience side effects. Clinical studies have shown these common side effects:

  • Common side effects:
    • Headache
    • Daytime sleepiness
    • Dizziness
    • Nausea
  • Less common side effects:
    • Vivid dreams or nightmares
    • Mild anxiety
    • Temporary depression
    • Irritability

Most side effects are mild and disappear when stopping the supplement. However, melatonin can interact with certain medications, including blood thinners and diabetes medications. Always consult with a healthcare provider before starting melatonin, especially if you’re taking other medications.

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Last Updated: September 1, 2025

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