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Research shows that while melatonin is generally safe for short-term use, some people may experience side effects:

  • Common side effects: Headaches, dizziness, nausea, daytime sleepiness
  • Less common effects: Vivid dreams, nightmares, mild anxiety
  • Rare side effects: Depression, mild tremors, mild anxiety, abdominal cramps

Long-term effects are still being studied. Melatonin can interact with various medications including blood thinners, diabetes medications, and immunosuppressants. Always consult a healthcare provider before starting supplementation, especially if you’re pregnant, nursing, or taking other medications.

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Last Updated: October 27, 2025

Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult with a healthcare provider before making health decisions.

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