While melatonin is generally considered safe for short-term use, studies have documented several possible side effects:
- Common side effects: Headache, dizziness, daytime sleepiness
- Less common effects: Nausea, mild anxiety, temporary depression
- Rare side effects: Vivid dreams or nightmares, mild tremor
Long-term use may affect hormonal development in children and teenagers. Melatonin can also interact with various medications, including:
- Blood thinners
- Blood pressure medications
- Diabetes medications
- Immunosuppressants
Pregnant and breastfeeding women should avoid melatonin supplements due to limited safety data. Always consult healthcare providers before starting melatonin, especially if you have existing medical conditions.
✓ Expert Reviewed: This content has been reviewed by qualified professionals in the field.
Last Updated: October 19, 2025
Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult with a healthcare provider before making health decisions.
Editorial Standards: Our Medical Content StandardsThe Health Research Team is a collaborative network of healthcare professionals, graduate researchers, and medical science students dedicated to synthesizing peer-reviewed health research for public education. Our interdisciplinary approach combines expertise from nutrition science, physiotherapy, nursing, and medical research to provide comprehensive, evidence-based health information.Click to read our Editorial Policy in details - Medical Oversight: All health information is overseen by board-certified physicians and follows FDA guidelines for health content