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Studies indicate that melatonin typically takes 30-60 minutes to reach peak levels in the blood. However, timing can vary based on several factors:

  • Formulation type: Sublingual tablets work faster than regular pills
  • Individual metabolism
  • Dosage amount
  • Food consumption (taking it with food may delay absorption)

For optimal results, take melatonin 30-60 minutes before your desired bedtime. Regular use may be needed for 1-2 weeks to see full benefits, particularly for chronic sleep issues. For jet lag, start taking it a few days before travel for best results.

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Last Updated: September 29, 2025

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