Table of Contents

Studies show that melatonin typically takes 30-60 minutes to begin working. The onset varies based on several factors:

  • Supplement form (liquid typically acts faster than pills)
  • Individual metabolism
  • Dosage amount
  • Whether taken with food

For optimal results, take melatonin 1-2 hours before your intended bedtime. Regular timing is important for establishing a consistent sleep schedule. Effects usually last 4-8 hours, though individual experiences may vary. If using for jet lag, start taking it at your destination’s bedtime a few days before travel for best results.

About the Author

✓ Expert Reviewed: This content has been reviewed by qualified professionals in the field.

Last Updated: September 27, 2025

Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult with a healthcare provider before making health decisions.

Editorial Standards: Our Medical Content StandardsThe Health Research Team is a collaborative network of healthcare professionals, graduate researchers, and medical science students dedicated to synthesizing peer-reviewed health research for public education. Our interdisciplinary approach combines expertise from nutrition science, physiotherapy, nursing, and medical research to provide comprehensive, evidence-based health information.Click to read our Editorial Policy in details - Medical Oversight: All health information is overseen by board-certified physicians and follows FDA guidelines for health content