Depression is typically treated with a combination of psychotherapy (talk therapy) and medication. Cognitive-behavioral therapy (CBT) is a widely used and effective form of psychotherapy for depression, which aims to change negative thought patterns and behaviors. Antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), can help regulate brain chemicals and alleviate symptoms. According to a study published in the Journal of the American Medical Association, a combination of therapy and medication is often more effective than either treatment alone. Other treatments, such as lifestyle changes (exercise, diet, and stress management), brain stimulation therapies, and alternative therapies like light therapy, may also be recommended.