Thiamine is generally considered safe, even in high doses, as excess amounts are excreted in urine. Research indicates no upper limit has been established because of its low toxicity. However, very high doses may occasionally cause:
- Mild stomach upset
- Allergic reactions (rare)
- Skin irritation
While overdose is unlikely, it’s still important to follow recommended dosages unless prescribed otherwise by a healthcare provider. Individuals taking thiamine supplements should inform their healthcare provider, especially if taking other medications or supplements.
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Last Updated: August 1, 2025
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